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Increased Risk of Parkinson's Disease in Parents and Siblings of Patients Ann Neurol 36:659-661, Payami,H.,et al, 1994 See this aricle in Pubmed Article Abstract We studied the incidence of Parkinson's disease in 586 first-degree relatives(parents and siblings)of 114 randomly ascertained white patients with idiopathic Parkinson's disease and in 522 first-degree relatives of 114 age-matched unrelated white control subjects.Sixteen percent of patients had a family history as compared to 4%of control subjects(p<0. 01).The age-specific cumulative incidence was higher in the first-degree relatives of patients than in the first-degree relatives of control subjects(p=0.007).The age-adjusted odds ratio was 3.5(95%confidence interval:1.3-9.4;p=0.014).These results suggest that genes contribute to the etiology of Parkinson's disease.

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(click to filter results - removes previous filter) familial genetic neurologic disorders Parkinson disease Parkinson disease,etiology of Parkinson disease,familial

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